We at Cell and Tissue Technology, are thrilled to introduce CellDrumTM, our ultra-thin, soft, and flexible PDMS cell culturing substrate, and CFArefer, our precise biomechanical measurement device, both designed to significantly enhance your biomechanical research capabilities.

CellDrumTM, available in thicknesses from 2 to 10 micrometres, provides a closer in vivo-like environment that enhances cellular reactions and overall cell health. The substrate’s elasticity, with tuneable Young’s modulus values, mimics the mechanical properties of natural tissues or the extracellular matrix more closely than conventional polystyrene culture flasks. This mechanical resemblance is critical in influencing cellular responses, including gene expression, cytoskeletal organization, and mechanotransduction pathways. The soft substrate is particularly beneficial for stem cell research, as it can modulate cell fate decisions by providing physical cues that mimic the natural stem cell niches. These cues promote natural differentiation pathways and improve the physiological relevance of in vitro models. CellDrumTM can be used independently to improve cell line production by offering more accurate and relevant cultivation conditions. This enhanced environment leads to more reliable and translatable results in your research and product development processes. Additionally, the substrate’s biocompatibility and optical transparency make it suitable for high-resolution imaging and real-time monitoring of cellular processes.

Recognizing the unique advantages of CellDrumTM, we designed CFArefer specifically to harness these properties for biomechanical measurements. By utilizing the CellDrum membrane, CFArefer can provide detailed insights into cellular mechanics that were previously challenging or otherwise highly invasive to obtain. This synergy between CellDrumTM and CFArefer allows researchers to explore new dimensions of cellular behaviour under varying mechanical conditions.

This state-of-the-art instrument provides precise biomechanical measurements, offering unparalleled insights into the cellular forces at play within cell layers under a variety of conditions. The CFArefer measures these forces in relation to changes in the stiffness of the free-standing PDMS CellDrum membrane, a feature that significantly enhances the scope and accuracy of biomechanical research. The CFArefer is also designed to support research in both biological and non-biological material testing, making it an invaluable tool for a wide range of scientific inquiries. By incorporating CFArefer into your laboratory setup, you can expand your experimental capabilities and leverage this innovative technology to gain access to valuable biomechanical data that was previously challenging or otherwise highly invasive to obtain.

With our products we hope to empower researchers to explore cellular mechanics with great detail and precision. Whether you are investigating the fundamental properties of cell layers or testing new materials, the CFArefer provides the data you need to drive your research forward. This enhanced understanding of biomechanical forces can lead to breakthroughs in various fields, including tissue engineering, regenerative medicine, and materials science. We believe the combined use of CellDrumTM and CFArefer can significantly benefit your research. 

Hereby we invite you to explore the advantages of CellDrumTM and CFArefer, and consider incorporating it into your cell cultivation protocols. Whether through incorporating the CFArefer directly into your laboratory work via purchase or engaging in specialized collaborative projects with us, we are committed to supporting your endeavours and advancing the frontiers of biomechanical research.

We look forward to the possibility of collaborating with you. Join us in harnessing the power of the CellDrumTM and CFArefer to unlock new dimensions of scientific discovery and innovation. Together, we can pave the way for cutting-edge advancements and transform the landscape of biomechanical research. 

Please feel free to reach out if you have any questions or would like to schedule a meeting. You can contact us here directly through the website, or send us an email which can also be found in the contact page. If you need more detailed information on any of our products or simply want to discover their working principles and find our published articles and research, check out the brochures that can be found on our website!