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CFArefer​

Sample volume 6 x 500 µl
Culture area Culture area 6 x 200 mm²
Measuring range pressure Measuring range pressure -125 to +125 Pa
Zero-point accuracy 0.08 Pa
Accuracy 3% of measured value
Measuring time (6 CellDrums) 180 s
Calibration automatic
Temperature control 30 to 40°C (+/- 0.4 °C)
Size (H x W x D) 140 x 185 x 435 mm
Weight 7.2 kg

CFArefer was designed specifically to harness the unique mechanical properties of the CellDrumTM technology for biomechanical measurements. By utilizing the CellDrum membrane, CFArefer can provide detailed insights into cellular mechanics that were previously challenging or otherwise highly invasive to obtain. This synergy between CellDrumTM and CFArefer allows researchers to explore new dimensions of cellular behaviour under varying mechanical conditions.

This state-of-the-art instrument provides precise biomechanical measurements, offering unparalleled insights into the cellular forces at play within adherent cell layers under a variety of conditions. The CFArefer measures these forces in relation to changes in the stiffness of the free-standing PDMS CellDrum membrane, a feature that significantly enhances the scope and accuracy of biomechanical research.

CFArefer enables advanced studies across a broad spectrum of adherent cell types, including applications in cardiomyocyte experiments focused on cell biomechanics and the Frank-Starling effect. These capabilities make it a powerful system for investigating contractile responses and mechanical adaptation in living cell layers. The CFArefer is also designed to support research in both biological and non-biological material testing, making it an invaluable tool for a wide range of scientific inquiries. Furthermore, its in vitro approach promotes non-animal or minimized animal testing methodologies, providing an ethical and efficient alternative for high-precision biomechanical assessment. 

By incorporating CFArefer into your laboratory setup, you can expand your experimental capabilities and leverage this innovative technology to gain access to valuable biomechanical data that was previously challenging or otherwise highly invasive to obtain.

Watch our video below for more information on how the CellDrum Technology and CFArefer work:

Human Endothelial (EC)-Smooth Muscle Cell (SMC) Co-culture on CellDrum (green: SMCs, red: ECs, blue: cell nuclei)

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